Google DeepMind's AlphaGenome Atlas

AlphaGenome Atlas, released by Google DeepMind on September 8, 2026, is a free academic platform containing AI-predicted molecular effects for all 9 billion possible single-nucleotide variants in the human genome. The dataset is 1 petabyte, more than 30 times larger than the AlphaFold Database. The platform introduces the AlphaGenome Variant Impact (AVI) score, which combines outputs from AlphaGenome and AlphaMissense into a single pathogenicity ranking spanning both protein-coding and non-coding genomic regions. DeepMind states the AVI score provides "best-in-class performance across many variant pathogenicity and rare disease benchmarks." External collaborators applied the score to identify a previously overlooked variant in the DNM1 gene associated with epileptic encephalopathy, with experimental validation confirming the result. Applying Atlas to UK Biobank whole-genome data from over 54,000 participants found 22% more non-coding genetic associations than conventional methods; focusing on the 1% of non-coding variants Atlas rated most impactful, researchers identified 19 genetic regions. Academic access is free through a web portal and API; commercial access through Google Cloud is planned.